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If nausea, vomiting, or diarrhea is severe at a given dose, the standard approach is to remain at the current dose for an additional 4 weeks before attempting escalation

Muller, D

Central nervous system GLP-1 receptors are distributed throughout brain regions implicated in depression, including the hippocampus, prefrontal cortex, and nucleus accumbens

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This approach reduced the potential for confounding factors that could bias the results, such as differences in individual health status or baseline risk