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The influence of vitamin D on glutathione becomes particularly significant when co-supplemented with calcium, as it upregulates glutamate cysteine ligase and glutathione reductase, two key enzymes required for GSH synthesis (109)

10.3390/ijms20122873 Int

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This effect occurs through weight loss, improved insulin sensitivity, reduced hepatic VLDL production, and decreased postprandial lipemia, though individual responses vary