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Oz HS, Chen TS

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For example, other drugs that slow gastric motility (such as opioid analgesics) may intensify gastrointestinal symptoms

95% CI 0.66, 0.75)

For those not yet ready for standard titration, microdosing tirzepatide offers an alternative approach that starts even lower than 2.5 mg

These observations were supported by our mutagenesis studies, where mutations R299 ECL2 A in GLP-1R, R289 ECL2 A in GIPR and I194 2.67b K in GCGR caused variable decreases in retatrutide potency (by 3.7-fold, 4.6-fold and 36.0-fold, respectively), while S297 ECL2 A in GCGR slightly increased retatrutide potency