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Sophie Dix (BSc, PhD) Published: 13 October 2025 | Updated: 18 June 2026 Updated: 18 June 2026 Reading time: 5 minutes Quick navigation: Mounjaro is one of the most effective weight loss treatments available, but recent UK price increases from Eli Lilly, the manufacturer of Mounjaro, means many people are looking for affordable alternatives
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In the PIONEER 4 trial, Rybelsus 14 mg reduced body weight by around 4 kg over 26 weeks, which works out at roughly 4 to 5% for many participants
doi: 10.1371/journal.pone.0048175 93 RohJLJangHKimEHShinD
Neurological symptoms deserve particular attention
This extended duration is why splitting doses into smaller, more frequent injections typically does not improve efficacyyour receptor saturation remains relatively constant
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