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Perhaps the most compelling argument that peripheral GLP-1 does not contribute to energy balance is that deleting the preproglucagon gene from the GI tract modestly impaired oral glucose tolerance and increased gastric emptying but had no effect on food intake or bodyweight despite almost completely eliminating circulating GLP-1 (85)

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Lee, PharmD, MAS, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Dr, Mail Code 0719, Pharmaceutical Sciences Bldg, La Jolla, CA 92093 ([email protected])

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