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The FDA has raised concerns about the increased risk of dosing errors, improper storage and fraudulently labeled GLP-1s from compounding pharmacies

195200 Supraphysiological concentrations of GIP could potentially activate GIPRs on L-cells, enhancing GLP-1 secretion

11,120 Knocking out or inhibiting the action of one or both of the incretin receptors results in some expected and unexpected phenotypes

Kounatidis D, Vallianou NG, Tsilingiris D, Christodoulatos GS, Geladari E, Stratigou T, et al

Potential Benefits of Microdosing GLP-1 RAs Reduced Side Effects: Lower doses minimize gastrointestinal discomfort, which can improve patient adherence and overall treatment tolerability

Before Ozempic, you might have been eating 2,200 calories a day