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They are generally more pronounced and longer-lasting than those seen with short-acting peptides due to its prolonged half-life

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Freezing is listed separately as causing crystallization and inactivation immediately on thawing

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Age and level of alcohol consumption were analysed as continuous variables, modelled non-linearly using restricted cubic splines (with three knots placed at the 5, 50, and 95% percentiles) to allow for flexible associations without arbitrary categorisation