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PMC 18523

13 , 14 , 16 , 18 , 20 Induction of oxidative stress with glutathione depletion through buthionine- S,R -sulfoximine, oral exposure to H 2 O 2 , or social defeat model through resident-intruder paradigm has been shown to be associated with anxiety and/or depressive behaviors in rodents tested with elevated plus maze, forced swim test and uncontrollable stress models

the largest Phase IIb trial with 536 participants failed to meet its primary efficacy endpoint, leading to development discontinuation in 2007

Dosage In all cases strictly abide by your doctor's prescription

W., Carter, V