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Weight is regained by most people after stopping medication unless new healthy habits are established

Initial Phase 1 and 2 clinical trials indicate that orally active forms of these types of drugs produce weight loss in humans comparable to that obtained with injected tirzepatide and semaglutide [69,70], suggesting they can be effectively administered orally

Repeated high-temperature events can lead to permanent capacity loss and increased internal resistance

It is also imperative for potential patients to have realistic expectations about the treatment, including what it can achieve, and the timeframe for which these changes should be seen

Compared with placebo, semaglutide was shown to predict reductions in heavy drinking over time and reduce the number of cigarettes per day among smokers