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doi: 10.3389/fimmu.2022.1039241 202 CantoniOZitoEGuidarelliAFioraniMGhezziP

The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

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For pigment specifically, a randomized, vehicle-controlled trial found topical tretinoin significantly improved melasma (a randomized vehicle-controlled trial showing topical tretinoin improves melasma), and a separate vehicle-controlled study confirmed the benefit specifically in patients with darker skin (a vehicle-controlled trial of topical tretinoin for melasma in darker skin)

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