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USA 102 , 761766 (2005)

[11] Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine. Accessed: Nov

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Cell 161: 215227 HajduCronin YM, Chen WJ, Patikoglou G, Koelle MR, Sternberg PW (1999) Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans : the RGS protein EAT16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity

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These preclinical findings further implicate glucagon activation as the distinguishing factor between incretin receptor mono-, dual-, and triagonists, and they point to unimolecular polypharmacology as an efficient way to target several mechanisms causing obesity