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doi:10.1016/s0076-6879(02)45028-8

For those dealing with hyperpigmentation and melasma, tretinoin can be an appealing option

Fleenor, D., Arumugam, R

The directional migration is mediated by secreted chemokines that form a concentration gradient towards the site of inflammation (Koopmann and Krangel, 1997)

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In contrast, FGF23 binds to the KlothoFGFR complex and activates the Mitogen-Activated Protein Kinase/Extracellular signal-Regulated Kinase 1 and 2 pathway, leading to the suppression of CYP27B1 and upregulation of the catabolic enzyme 24-hydroxylase (CYP24A1), which accelerates the degradation of 1,25(OH)D (13)