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Placebo-Controlled A study design where one group receives the actual treatment while another receives an inactive substitute (placebo)

Edges may be smooth, irregular, or red & inflamed

Seek urgent medical help if you experience: severe or continuous abdominal pain persistent vomiting or inability to keep fluids down signs of infection (fever, redness, swelling) shortness of breath , chest pain , or sudden weakness Both treatments must be taken under medical supervision

Future perspectives Over the years, research has made significant progress in elucidating the mechanism of iron overload and the management of associated disorders in -thalassemia

A recent Mendelian randomized study found that some antioxidants (-carotene, lycopene and uric acid), vitamins (A, B6, B12, C, D and K1), and minerals (Ca, Mg, Cu) are causally related to the development of metabolic syndrome (Li and Song, 2023)

Demirtzoglou, G