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Consequently, ACs modulation of -synuclein, caspase-3, and MAP2 could underlie its neuroprotective effects, positioning it as a promising therapeutic candidate for alleviating PD symptoms
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MFN2, a key mediator of mitochondrial fusion, facilitates mitophagy through the recruitment of Parkin when phosphorylated by PINK1 [90, 91]
The Triglycderide (TyG) index was calculated as ln [TG (mg/dL) FBG (mg/dL)/2], derived from previous studies 112,113 and has been shown to be superior to homeostasis model assessment insulin resistance (HOMA-IR) index in predicting insulin resistance 114
Anti inflammatory and antioxidant signaling Evidence sources : cell and animal work, narrative and mechanistic reviews Confidence : moderate on signaling changes Main caveats : shifts in biomarkers are not the same as demonstrated clinical benefit
