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Gluten-induced immune activation: In controlled gluten-challenge studies larazotide attenuated some symptom and immunologic responses to gluten versus placebo, though barrier-permeability endpoints were mixed [2]

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Additionally, in phase 2 studies in people with MASH and liver fibrosis, survodutide not only significantly improved liver steatosis, but also led to histologic improvement of MASH without worsening fibrosis in 4362% of participants, versus 14% with placebo [41]