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Discovery and Research Timeline Researchers identified the first estrogen-related receptor as an orphan nuclear receptor related to, but distinct from, classical estrogen receptors

Fusion loop I therefore changes its length from four to 15 residues and rolls up, forming a short (2 turn 3 10 ) helix while keeping contact with the MPR by positioning W174, F175, Y179, F182 and M183 towards the hydrophobic cleft of the MPR (Figs

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