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Bumetanide for core symptoms of autism spectrum disorder (BAMBI): a single center, double-blinded, participant-randomized, placebo-controlled, phase-2 superiority trial

High doses are generally considered safe, though some people may experience minor side effects

Different handling requirements apply to unreconstituted powder versus reconstituted solution

Even absent these logistical hurdles, pharmaceutical companies might not want to invest in clinical trials

Sadly some people with "traditional P,A." either do not produce Intrinsic Factor or if they do, they also produce an antibody which destroys it and it is then called "Autoimmune Pernicious Anaemia"

Supplementing with a safe dose of Biotin alongside your B12 injections will resolve this skin concern in many cases