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NO is synthesized by at least three isoforms of NO synthase (NOS): - in the endothelium by endothelial NOS (eNOS), - in nerve cells mainly by neuronal NOS, - in macrophages by inducible NOS

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The most studied preclinical doses are 10 g/kg and 10 ng/kg administered subcutaneously, intraperitoneally, or orally

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10.1126/scitranslmed.aax6337 46 JeonD.HillE.MosemanJ