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However, there is growing pressure from patients and healthcare professionals in various fields to use these drugs beyond approved indications to achieve benefits across multiple organ systemscardiovascular, musculoskeletaland to obtain anti-inflammatory effects

In the STEP clinical trial program, 2.4 mg was the target maintenance dose that produced an average 14.9% total body weight reduction at 68 weeks (Wilding et al., New England Journal of Medicine 2021)

Finally, exercise is vital for injury prevention, as it strengthens muscles, tendons, and ligaments, enhancing joint stability and reducing the risk of musculoskeletal injuries

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It naturally binds with the precursor of eumelanin, the pigment responsible for dark complexions, and creates pheomelanin, a lighter pigment

doi: 10.1002/jcph.1097 [DOI] [PubMed] [Google Scholar] 16