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Our group recently identified oxamic hydrazide as a potent CSE inhibitor by screening a large chemical library of 161,600 compounds ( 50 value of 13 M with high selectivity over other PLP-dependent enzymes including CBS, alanine aminotransferase and methionine -lyase

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Meanwhile, the ectopic deposition of in the ovaries and liver directly impairs oocyte mitochondrial function and energy metabolism, resulting in the so-called lipotoxic oocyte phenotype (64, 65)