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Metformin, which is sold under the brand names Fortamet and Glumetza, has been shown to cause a modest weight loss within the first few months of starting the medication

Fundam.Clin Pharmacol 2010;24(5):595-605

Exendin-4 Protects Human Retinal Pigment Epithelial Cells from H2O2-Induced Oxidative Damage via Activation of NRF2 Signaling

However, as described earlier, its favourable effects on lipolysis and energy expenditure while reducing food intake make it an attractive option, especially if combined with the insulinotropic action of GLP-1

15,22 Comprehensively, using Aib 2 is likely to only minimally influence the GLP-1 and GIP activities

The data showed two times more cases of macular degeneration in the GLP-1 patients