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Difficulty Achieving Long-Term Weight Loss Individuals who have made consistent efforts with diet and physical activity but continue to struggle with sustained weight management may benefit from medications that target appetite regulation

Moreover, it is increasingly recognized that weight loss itself primarily serves as a surrogate marker for favorable changes in body fat distribution, particularly reductions in ectopic fat depots such as visceral adipose tissue and intrahepatic lipid content, both of which are strongly associated with ASCVD risk (80, 81)

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J Endocrinol (1993) 138(1):15966

Decision to Initiate GLP-1 Therapy Richards endocrinologist is considering adding a GLP-1 receptor agonist to improve glycemic control and reduce weight