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When addressing dimeric protein targets, the ability of dimeric therapeutic agents to antagonize paired receptors within a single molecular entity potentially offers superior therapeutic efficacy and target selectivity 15,16

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Indeed the upregulation of NRF2 (nuclear factor, erythroid-derived 2-like 2 factor) has been observed in a wide array of tumors including breast, ovarian, prostate, skin, lung and pancreas [32,44]

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