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Diclofenac penetrates into the synovial fluid

Treatments to Avoid Corticosteroid injections, while providing short-term pain relief, are toxic to tendons, ligaments, and cartilage

What the research shows: A phase 2 randomized, double-blind, placebo-controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023) enrolled 338 adults with obesity

Common adverse effects include nausea, vomiting, diarrhea, and decreased appetite

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The ability to rapidly reduce inflammatory signaling during these acute episodes is critical for preventing permanent organ damage