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Endothelial GLP-1 (glucagon-like peptide-1) receptor mediates cardiovascular protection by liraglutide in mice with experimental arterial hypertension
172 The challenges in developing these drugs include ensuring that they can effectively mimic the biological activity of large molecule GLP-1RAs while maintaining efficacy and selectivity
Expert Opinion on Drug Safety, 14 (2), 207218.
In animal experiments, the GLP-1RA liraglutide was found to stimulate the secretion of ANP by increasing the levels of Epac2, which is a downstream target of GLP-1R signaling in cardiomyocytes (132), However, this finding seemed to contradict the results of clinical studies in which no increase was observed in the levels of ANP in healthy people and patients with T2MD
In the GLP-1 RA vs SGLT-2 inhibitor cohort, there was no difference in the adjusted HR of suicide or suicide attempts between patients treated with GLP-1 RAs compared with patients treated with SGLT-2 inhibitors after 1 year of follow-up (HR 365 0.93 [0.57;1.52]), see Table 2
Strong presence of major pharmaceutical companies and early adoption of novel therapies and favorable reimbursement policies boost the regional market growth
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