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It also activates pathways like Egr-1, NAB2, and JAK-2

The evidence is preclinical (mouse and cell studies)

In particular, it has been shown to reduce immediate allergic reactions and thermal hyperalgesic responses in sensitized animals

When presented together as a blend, these peptides appear to yield synergistic results, possibly stimulating the pituitary gland and triggering the release of growth hormone

I should say that they only respond to the particular stimulus, the pepper, the cold, the heat, et cetera, that will evoke an electrical signal, but the electrical signals are a common language that all neurons use

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