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Hepatic Impairment Hepatic GH receptor expression is reduced in cirrhosis, meaning sermorelin-driven GH pulses produce less IGF-1 per unit GH

doi: 10.1007/s13238-020-00789-5 47 LiSLuZSunRGuoSGaoFCaoBet al

The strongest, most consistent human data for Ipamorelin remain limited, and much of the timeline reasoning is extrapolated from GH physiology rather than large Ipamorelin-specific trials