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Importantly, the presence of side effects may also serve as a clinical cue that the appetite-regulating mechanism is active , though any severe or persistent symptoms warrant reevaluation of dose or co-therapy timing

doi: 10.1371/journal.pone.0026998 42 GuabirabaRRodriguesDRMannaPTChollotMSaint-MartinVTrappSet al

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Lots of publications is not the same as evidence. 2