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KD lowers insulin, causing a decrease in IGF-1, which consequently leads to an increase in IGFBP-3 (191)

The considered standard variable modifications were N-terminal acetylation, N-terminal glutamine conversion to pyroglutamate and methionine oxidation

The first signs, such as reduced skin elasticity or joint discomfort, can result

In addition, morphometric analysis revealed a reduction in preantral and Graafian follicles, along with an increase in atretic follicles, indicating disruption of ovarian histoarchitecture

Collectively, these findings support the hypothesis that retrograde transport may mediate the retrieval of VSRs from MVBs

doi: 10.1007/s00424-020-02352-x 128 RyszJ.FranczykB.awiskiJ.OlszewskiR.Ciakowska-RyszA.Gluba-BrzzkaA