fda semaglutide compounding enforcement october 2025 New project announcement: HHS‑OIG is taking a closer look at FDA's oversight of compounded GLP‑1 drugs. Although shortages ended in 2025, some facilities may still be producing these drugs at scale. Our Novo Nordisk Calls for FDA

FDA-Approved Dosing Schedule The approved dosing protocol for Semaglutide starts at a low dose to allow your body to acclimate and minimize potential side effects: Starting Dose: 0.25 mg weekly for the first four weeks

While theyre fundamentally similar medications, they differ slightly in their mechanism of action: Wegovy (semaglutide) is a GLP-1 agonist Zepbound (tirzepatide) is a dual agonist: GLP-1 + a glucose-dependent insulinotropic polypeptide (GIP) Both semaglutide and tirzepatide affect the hypothalamus and the hedonic eating centers, the brains center of appetite and cravings

Cravings for water as well as for food diminish

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May share pathway overlap or increase specific side effects

Week 12 and beyond: maintenance phase Once you reach your maintenance dose and have been stable for several weeks, diarrhea becomes much less common