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2) The study conducted by the research team of Li et al meticulously delineated the role of FOXO4 in Leydig cell senescence and its impact on male fertility, while also demonstrating the therapeutic efficacy of FOXO4-DRI in alleviating age-related testosterone and spermatogenesis insufficiencies

The histamine released causes blood vessel dilation (redness), increased vascular permeability (swelling), and nerve ending stimulation (itching and pain)