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mTOR inhibition not only impaired mitochondrial ATP turnover, but abolished the positive effect of Exendin-4 on this parameter (Fig
Fischer GM, Kotrotsou A, Ahmed S, O'Neal P, Sahnoune I, Yennu-Nanda VG, Hudgens C, Knighton B, Colen R, Tetzlaff MT, Davies MA
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Research on MOTS-c in ovariectomized mice (a model for postmenopausal metabolic dysfunction) showed reduced fat accumulation in white adipose tissue, increased brown fat activation, and improved insulin sensitivity after just 5 weeks of treatment
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