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10.1186/s42269-022-00792-2 11 BakrS

We express our gratitude to Tania Reyes-Izquierdo and Zbigniew Pietrzkowski (Applied Bio Clinical, Applied BioClinical Lab, Futureceuticals, Inc.) for their comments and suggestions in the preparation of this article

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Overall, existing inhibitors suffer from insufficient selectivity, highlighting the urgent need for LONP1-specific agents developed through advanced approaches such as cryo-electron microscopy and molecular dynamics simulations to expand therapeutic options

Broth, salted foods, and an electrolyte supplement taken twice daily are the practical approach