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Additionally, several transcription factors involved in ferroptosis, including tumor protein 53 (TP53), NFE2L2/NRF2, and activating transcription factor (ATF3), have diverse functions in modulating ferroptosis sensitivity using transcription-dependent or transcription-independent techniques ( 2.1 Ferroptosis and iron metabolism Ferroptosis, the process of acquiring, using, storing, and eventually excreting iron, relies heavily on iron metabolism ( 2+ into the cells after iron reductase converts Fe 3+ in the intestinal epithelium (Richardson and Ponka, 1997)

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doi: 10.1002/jsfa.7880, 31

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This bioactive compound was first discovered in human blood plasma and later found in saliva and urine, where it plays a fundamental role in tissue repair and regeneration processes throughout the body

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