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Combining the different arms of gut microecology, iron metabolism, cell death in this hypothesis, it offers a new explanatory model for investigating gut-joint axis in OA and proposes possible targets for OA intervention strategies including changes of gut microbiota or ferroptosis

It interferes with the trafficking of melanogenic enzymes and inhibits tyrosinase activity and melanosome transfer in several ways

Autophagy 14 , 671684 (2018)

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