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The ice crystal formation physically damages the peptide structure, and this damage does not reverse when the solution thaws

[DOI] [PubMed] [Google Scholar] 112.Philippi N., Vinzio S., Collongues N., Vix M., Boehm N., Tranchant C., Echaniz-Laguna A

TB-500 is also administered via subcutaneous injection, but the schedule is different: one or two injections per week rather than daily