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This was evidenced by RBC Prdx2 in G6PD-deficient infants, with a higher proportion shown to maintain the oxidized state and are poorly reactivated after peroxide challenge (Table 1 shows previously reported kinetic parameters of G6PD activity attributed to different variants ( TABLE 1 Kinetic parameters in G6PD enzyme activity between some genetic variants against G6PD B (normal)

Campos-Bedolla P, Walter FR, Veszelka S, Deli MA

2-D electrophoresis was performed to elucidate the reasons for this discrepancy, and the results indicated obvious changes in central metabolism and amino acid metabolism in the penta-mutant

A larger follow-up RCT (n=72 older adults) confirmed these findings, additionally demonstrating improvements in gait speed (+0.14 m/s), grip strength, 6-minute walk distance, waist circumference reduction, and systolic blood pressure reduction (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]