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Studies have found that lower strengths of tretinoin yield comparable photoaging benefits to higher strengths (0.025% versus 0.1%) but with significantly lower irritation

We observed reduced DNA degradation upon depletion of SMARCAL1, ZRANB3 and HLTF, providing evidence for a role of these motor proteins in generating reversed forks that become destabilized in the PDS5B deficient background

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MPA, microscopic polyangiitis

High ROS level in HGPS cells could be attributed to the large DNA damage and subsequently resulting in an underlying defect in early senescence in HGPS cells (Huang et al., 2005

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