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But surgery is a little different
At Southern Weight Loss (Mercy Hospital, Dunedin), we frequently see patients who: Have plateaued on GLP-1/GIP therapy Cannot tolerate escalation Are concerned about long-term medication cost Seek definitive metabolic intervention Mechanism of action Tirzepatide (Mounjaro) Tirzepatide is a dual GIP and GLP-1 receptor agonist that: Enhances glucose-dependent insulin secretion Suppresses glucagon Slows gastric emptying Reduces appetite centrally Weight loss occurs via hormonal appetite suppression
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A sigmoidoscopy revealed severe colitis with ulcerations, severe edema, and friable mucosa from the anus to 20 cm proximally
Complaint 5: Results Not Guaranteed A small group of patients express disappointment when weight loss outcomes fall short of expectations
