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The dysesthesia side effect (tingling or numbness) at higher doses is unique to retatrutide and resolves for most researchers, but it is an additional consideration

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Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus

For me, things like fresh salads or plain grilled chicken are much easier to tolerate than, say, a simmering stew or anything fried

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Pain, reflux, urination, and hot flashes can also fragment sleep