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Individuals with a history of cancer, active tumors, or strong genetic predisposition to cancer should avoid IGF-1 use entirely

What researchers study these compounds for Across published preclinical and early clinical work, this class is examined for: Telomere length and telomerase activity in cell models Mitochondrial energy output and resistance to stress NAD+ levels and the downstream enzymes (sirtuins) that depend on it Oxidative-stress markers and antioxidant capacity Age-related changes in cognition, metabolism, and tissue function in animal models Most of the strongest evidence is preclinical cell cultures and animal studies which is important context when reading any longevity claim

[DOI] [PubMed] [Google Scholar] 63.Huang P, Kishida S, Cao D, et al