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We believe this U-shaped dose-response curve occurs due to the possibility that low-dosed TAT-DAT NT returns the abnormally low level of dopaminergic signaling to the physiological range, and therefore normalizes the hyperactivity of SHR rats

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Anaplastic, Medullary, and Biologically Aggressive Differentiated Thyroid Cancer: Integration of Systemic Therapy with Surgery, Grand Rounds Presentation

Arcaro et al

It has been demonstrated that oxidative stress and excessive generation of ROS affect mitochondrial morphology 30