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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

What is Vitamin B12 and Why is it Important

The use of folic acid for the treatment of pernicious anemia patients began with the availability of synthetic folic acid in 1945 (79)