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In summary, tirzepatide modulates metabolic and inflammatory pathways that may enhance airway stability in obesity-related OSAS (Figure 2)

While trials used 6 mg, 12 mg, and 36 mg doses, Lilly conducted pharmacokinetic studies to establish equivalent doses of 9 mg, 14.5 mg, and 17.2 mg for manufacturing

This approach minimizes the appetite rebound that can occur during a washout but may increase GI side effects during the first 2 weeks of retatrutide as both receptor systems are in flux

Future studies with bigger group sizes may detect fine differences in the dynamics of breath hydrogen, gut hormone secretion, or plasma SCFA

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