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Alternative Therapies in Health and Medicine (2025) 11

These hormones then bind to specific G-protein coupled receptors (GPCRs) located in various tissues [160]

Andreu, I., Granero-Moya, I., Chahare, N

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However, Sermorelin activates only the GHRH receptor pathway and produces a brief GH pulse (10-12 minute half-life) that does not sustain the IGF-1 elevation many patients need for meaningful body composition and anti-aging results

Co-ligand bonding and the trans effect