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The sulfotransferase enzyme activity that converts minoxidil to its active form varies genetically

This signaling cascade subsequently elevates ACSL4 expression, driving lipid peroxidation and ferroptosis through the ACSL4/lysophosphatidylcholine acyltransferase 3/arachidonate lipoxygenase 15 axis, as demonstrated in both in vitro and in vivo models of severe acute pancreatitis (114)

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The surrounding microenvironment further shapes these metabolic preferences

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