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Nat Genet 19:379383 Mariadason JM, Bordonaro M, Aslam F, Shi L, Kuraguchi M, Velcich A et al (2001) Down-regulation of -catenin TCF signaling is linked to colonic epithelial cell differentiation

PlexusDx personalized protocols use a dose titration approach where your healthcare provider may recommend stepping up from 0.25 mg to 0.5 mg to 1 mg to 2.4 mg over successive weeks

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Modest, at roughly 5 to 10 percent of body weight in responders over 56 weeks, achieved through central nervous system modulation rather than slowed gastric emptying or incretin stimulation