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However, they can indirectly contribute to muscle loss because they: Reduce appetite dramatically Lower calorie intake Sometimes, reduce protein consumption Lead to faster weight loss In other words: Muscle loss is usually related to rapid weight reduction and inadequate nutrition not because GLP-1 medications specifically target muscle

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TRPA1 protein expression summary - The Human Protein Atlas n.d Accessed 19 Jul 2023 Tissue expression of GPR6 - Summary - The Human Protein Atlas n.d Accessed 19 Jul 2023 TRPV4 protein expression summary - The Human Protein Atlas n.d Accessed 19 Jul 2023

doi:10.1016/j.repbio.2019.07.005

That contrast generalist versus specialist frames this comparison

doi: 10.1111/resp.13838, 3