FOXO proteins undergo various post-translational modifications (phosphorylation, acetylation, ubiquitination, methylation, glycosylation) that influence their biological function in the central nervous system
In fact, some even claim that increasing your intake of vitamin B12 can help fight fatigue, boost energy levels, and speed up your metabolism
This also presents an ongoing problem with autoimmunity, where the immune system is constantly attacking the migrating motor complex - an issue that I am sure will be studied further
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