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The SELECT cardiovascular outcomes trial showed that semaglutide 2.4 mg significantly reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) in patients with established cardiovascular disease and overweight or obesity, even without type 2 diabetes

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GI tolerability : SURPASS-2 suggested comparable or slightly better GI tolerability with tirzepatide at equivalent efficacy levels

Brains were then fixed for 24 h at 4 C in 4% PFA and then transferred to 15% sucrose for 24 h, followed by 24 h in 30% sucrose at 4 C

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